ATLA/Chak De! India: The International Indian women's hockey team has always lived in the Avatarverse, plays a possibly-fantastical version of field hockey, and Komal and Toph are BFFs/girlfriends/get in lots of fights/kick ass and take names.
Cabin Fever/Twin Peaks: Albert, now working for the CDC, must investigate reports of a flesh-eating virus. Dale is somehow involved in the investigation, too, whether as a consultant or if he actually comes along. They run into Deputy Winston, who may have contacted the CDC to begin with. Hilarity ensues--especially once Dale remembers you need water to make coffee.
Disgaea 4: Desco/Fuka FOREVER. They could share sodas/candy/ramen or cuddle or hold hands/tentacles or kill lots of monsters or read shoujo manga/watch romantic J-Dramas together or just....CONSENSUAL ROMANCE BETWEEN A HUMAN AND A TENTACLE-CREATURE OMG <3 <3 <3
Ga-Rei: Zero: An epic AU where ( spoilers for episode 9 )